Lupus ampolloso: un verdadero reto diagnóstico y terapéutico
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Palabras clave

Lupus cutáneo, lupus ampolloso , belimumab.

Cómo citar

1.
Escorcia Charris E, Carbono Camargo J, Salas Siado J, Coronell Buzon L. Lupus ampolloso: un verdadero reto diagnóstico y terapéutico. Biociencias [Internet]. 27ene.2018 [citado 27may2019];13(1). Available from: http://ojsinvestigacion.unilibrebaq.edu.co/ojsinvestigacion/index.php/biociencias/article/view/895

Resumen

El lupus eritematoso sistémico (LES)  es una enfermedad de tipo autoinmune en donde existen múltiples factores  que inducen una respuesta inmunológica no controlada en un individuo que genéticamente está predispuesto, presentándose una variedad de manifestaciones clínicas que muchas veces se convierten en un verdadero reto diagnóstico y terapéutico como es el caso de sus presentaciones en piel. Describiremos a continuación un caso de un paciente género masculino con diagnostico LES  con lesiones cutáneas extensas severas con diagnóstico clínico y histopatológico sugestivo de lupus ampolloso refractarias a tratamiento estándar con corticoterapia e inmunomoduladores  con evolución tórpida en su curso, que requiere posteriormente inicio de terapia biológica con  Belimumab observándose una remisión clínica significativa de las lesiones y contribuyendo además a disminuir las dosis de corticoides utilizadas desde su ingreso  . Se revisarán aspectos en relación del LES en hombres en lo que refiere a epidemiologia, manifestaciones cutáneas, hallazgos histopatológicos, diagnóstico diferencial y opciones terapéuticas actuales.

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